Treatment of experimental Pneumocystis carinii infection by combination of clarithromycin and sulphamethoxazole
Identifieur interne : 002C06 ( Main/Exploration ); précédent : 002C05; suivant : 002C07Treatment of experimental Pneumocystis carinii infection by combination of clarithromycin and sulphamethoxazole
Auteurs : Jeffrey Alder [États-Unis] ; Michael Mitten [États-Unis] ; Nate Shipkowitz [États-Unis] ; Lisa Hernandez [États-Unis] ; Yu-Hua Hui [États-Unis] ; Kennan Marsh [États-Unis] ; Jacob Clement [États-Unis]Source :
- Journal of Antimicrobial Chemotherapy [ 0305-7453 ] ; 1994.
Abstract
The efficacy of clarithomycin and sulphamethoxazole for treatment of experimental Pneumocystis carinii infection was investigated. Rats were immunosuppressed with dexamethasone and inoculated intratracheally with 5 × 106 P. carinii cysts. After 2 weeks, the lung tissues were assayed for P. carinii cyst burden. The combination of clarithromycin and sulphamethoxazole caused a significantly greater reduction in cyst burden than either drug alone. Up to 50% of the rats treated with the combination of clarithromycin and sulphamethoxazole were negative for P. carinii cysts. Equivalent doses of the individual drugs given alone did not produce cures. The combination of clarithromycin and sulphamethoxazole was more than twice as effective as either drug alone. Clarithromycin combined with sulphamethoxazole in treatment of P. carinii infection could be especially useful since clarithromycin monotherapy provides safe and effective treatment against many other pathogens, including several that are associated with AIDS.
Url:
DOI: 10.1093/jac/33.2.253
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002070
- to stream Istex, to step Curation: 002070
- to stream Istex, to step Checkpoint: 001989
- to stream Main, to step Merge: 002C66
- to stream Main, to step Curation: 002C06
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Treatment of experimental Pneumocystis carinii infection by combination of clarithromycin and sulphamethoxazole</title><author><name sortKey="Alder, Jeffrey" sort="Alder, Jeffrey" uniqKey="Alder J" first="Jeffrey" last="Alder">Jeffrey Alder</name></author><author><name sortKey="Mitten, Michael" sort="Mitten, Michael" uniqKey="Mitten M" first="Michael" last="Mitten">Michael Mitten</name></author><author><name sortKey="Shipkowitz, Nate" sort="Shipkowitz, Nate" uniqKey="Shipkowitz N" first="Nate" last="Shipkowitz">Nate Shipkowitz</name></author><author><name sortKey="Hernandez, Lisa" sort="Hernandez, Lisa" uniqKey="Hernandez L" first="Lisa" last="Hernandez">Lisa Hernandez</name></author><author><name sortKey="Hui, Yu Hua" sort="Hui, Yu Hua" uniqKey="Hui Y" first="Yu-Hua" last="Hui">Yu-Hua Hui</name></author><author><name sortKey="Marsh, Kennan" sort="Marsh, Kennan" uniqKey="Marsh K" first="Kennan" last="Marsh">Kennan Marsh</name></author><author><name sortKey="Clement, Jacob" sort="Clement, Jacob" uniqKey="Clement J" first="Jacob" last="Clement">Jacob Clement</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:4872940DDB3A810A0D40FC5E792506CEC7FFDB43</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1093/jac/33.2.253</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-3DP9WBVF-H/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002070</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002070</idno><idno type="wicri:Area/Istex/Curation">002070</idno><idno type="wicri:Area/Istex/Checkpoint">001989</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001989</idno><idno type="wicri:doubleKey">0305-7453:1994:Alder J:treatment:of:experimental</idno><idno type="wicri:Area/Main/Merge">002C66</idno><idno type="wicri:Area/Main/Curation">002C06</idno><idno type="wicri:Area/Main/Exploration">002C06</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Treatment of experimental <hi rend="italic">Pneumocystis carinii</hi> infection by combination of clarithromycin and sulphamethoxazole</title><author><name sortKey="Alder, Jeffrey" sort="Alder, Jeffrey" uniqKey="Alder J" first="Jeffrey" last="Alder">Jeffrey Alder</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Anti-Infective Research Division, Abbott Laboratories, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Mitten, Michael" sort="Mitten, Michael" uniqKey="Mitten M" first="Michael" last="Mitten">Michael Mitten</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Anti-Infective Research Division, Abbott Laboratories, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Shipkowitz, Nate" sort="Shipkowitz, Nate" uniqKey="Shipkowitz N" first="Nate" last="Shipkowitz">Nate Shipkowitz</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Anti-Infective Research Division, Abbott Laboratories, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Hernandez, Lisa" sort="Hernandez, Lisa" uniqKey="Hernandez L" first="Lisa" last="Hernandez">Lisa Hernandez</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Anti-Infective Research Division, Abbott Laboratories, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Hui, Yu Hua" sort="Hui, Yu Hua" uniqKey="Hui Y" first="Yu-Hua" last="Hui">Yu-Hua Hui</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Anti-Infective Research Division, Abbott Laboratories, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Marsh, Kennan" sort="Marsh, Kennan" uniqKey="Marsh K" first="Kennan" last="Marsh">Kennan Marsh</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Anti-Infective Research Division, Abbott Laboratories, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Clement, Jacob" sort="Clement, Jacob" uniqKey="Clement J" first="Jacob" last="Clement">Jacob Clement</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Anti-Infective Research Division, Abbott Laboratories, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Antimicrobial Chemotherapy</title><idno type="eISSN">1460-2091</idno><idno type="ISSN">0305-7453</idno><imprint><publisher>Oxford University Press</publisher><date when="1994-02">1994</date><biblScope unit="vol">33</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="253">253</biblScope><biblScope unit="page" to="263">263</biblScope></imprint><idno type="ISSN">0305-7453</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0305-7453</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The efficacy of clarithomycin and sulphamethoxazole for treatment of experimental Pneumocystis carinii infection was investigated. Rats were immunosuppressed with dexamethasone and inoculated intratracheally with 5 × 106 P. carinii cysts. After 2 weeks, the lung tissues were assayed for P. carinii cyst burden. The combination of clarithromycin and sulphamethoxazole caused a significantly greater reduction in cyst burden than either drug alone. Up to 50% of the rats treated with the combination of clarithromycin and sulphamethoxazole were negative for P. carinii cysts. Equivalent doses of the individual drugs given alone did not produce cures. The combination of clarithromycin and sulphamethoxazole was more than twice as effective as either drug alone. Clarithromycin combined with sulphamethoxazole in treatment of P. carinii infection could be especially useful since clarithromycin monotherapy provides safe and effective treatment against many other pathogens, including several that are associated with AIDS.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Alder, Jeffrey" sort="Alder, Jeffrey" uniqKey="Alder J" first="Jeffrey" last="Alder">Jeffrey Alder</name></region><name sortKey="Clement, Jacob" sort="Clement, Jacob" uniqKey="Clement J" first="Jacob" last="Clement">Jacob Clement</name><name sortKey="Hernandez, Lisa" sort="Hernandez, Lisa" uniqKey="Hernandez L" first="Lisa" last="Hernandez">Lisa Hernandez</name><name sortKey="Hui, Yu Hua" sort="Hui, Yu Hua" uniqKey="Hui Y" first="Yu-Hua" last="Hui">Yu-Hua Hui</name><name sortKey="Marsh, Kennan" sort="Marsh, Kennan" uniqKey="Marsh K" first="Kennan" last="Marsh">Kennan Marsh</name><name sortKey="Mitten, Michael" sort="Mitten, Michael" uniqKey="Mitten M" first="Michael" last="Mitten">Michael Mitten</name><name sortKey="Shipkowitz, Nate" sort="Shipkowitz, Nate" uniqKey="Shipkowitz N" first="Nate" last="Shipkowitz">Nate Shipkowitz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002C06 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002C06 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:4872940DDB3A810A0D40FC5E792506CEC7FFDB43
|texte= Treatment of experimental Pneumocystis carinii infection by combination of clarithromycin and sulphamethoxazole
}}
| This area was generated with Dilib version V0.6.33. |  |